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Exercise
Alternate Name/Related Terms
  • Aerobic Exercise, Resistance Exercise, Weight Training
Principal Proposed Uses
  • Enhancing Survival in People With Severe Heart Disease, High Cholesterol and/or High Triglycerides, Hypertension, Reducing Falls in the Elderly
Overview

This article discusses the possible health benefits of exercise. For information on enhancing exercise ability, see Sports and Fitness Support: Enhancing Performance . For articles on specific exercise systems, see the articles on Tai Chi and Yoga .

One of the most obvious differences between modern life and life in the past can be found in the level of exercise. For the majority of people living in developed countries today, heavy physical exercise does not occur as a part of ordinary daily life, but must be deliberately sought out. Compare this to most of human history, in which heavy daily exercise was a requirement for survival. Even among the upper classes in 19th century Europe—to judge by a scene in Charles Dickens Pickwick Papers —going for a 10 to 20 mile walk by way of recreation was not be out of the ordinary course of events.

The human body was designed to use its physical capacities. However, for many of us, life has become a sedentary affair, moving from couch via car to office cubicle. While decreasing strenuous exercise does have some benefits, such as reducing injuries, it also presents major drawbacks. Inadequate exercise is undoubtedly a major contributor to the current epidemic of obesity, which in turn leads to diabetes, heart disease, and osteoarthritis.

Conversely, increasing one's level of exercise provides a wide variety of benefits. Besides enhancing strength and endurance and improving physical attractiveness, exercise is thought to enhance overall health as well as reduce symptoms in a number of specific ailments. However, while the many benefits of exercise appear self-evident, they can be quite difficult to prove in a scientific sense. The primary problem comes down to this: it is difficult, if not impossible, to design a double-blind study of exercise.

In a double-blind, placebo-controlled study, neither patients nor researchers know who is receiving a real treatment and who is receiving a placebo. The centrality of such studies is discussed in detail in Why Does This Database Rely on Double-blind Studies? We will discuss the subject here only in brief.

Consider the following scenario: A study (technically, an observational or epidemiological study) may note that people in a given population who exercise more develop heart disease at a lower rate than those who exercise less. From this, it is tempting to conclude causality: that exercise reduces heart disease risk. But such a conclusion might not be correct.

Observational studies only show association, not cause and effect. Studies of the type described above had long shown that women who used hormone replacement therapy (HRT) were less likely to develop heart disease. Furthermore, use of HRT was known to improve cholesterol profile. It seemed like a "slam-dunk" case. However, to researchers' surprise, when a giant double-blind study compared hormone replacement therapy against a placebo, the results showed that use of HRT actually increased heart disease risk.

It is now hypothesized that this apparent contradiction may be due to the fact that women who use HRT are generally of higher socioeconomic status than women who do not use HRT, and that it is this socioeconomic status, and not the HRT, that was responsible for the apparent benefits seen. Whatever the reason, it is now clear that HRT does not prevent heart disease, and that the conclusions drawn from observational studies were exactly backwards. Based on this, one must at least consider the possibility that people who engage in more exercise have other qualities that protect them from heart disease, and that it is these qualities, and not the exercise, that protects them. The problem here is that while it is possible to give a placebo that convincingly resembles HRT, it is difficult to conceive of a placebo form of exercise that patients and researchers wouldn't immediately identify as different from real exercise.

Besides observational studies, other forms of scientific research involving exercise remain similarly inadequate. For example, consider the numerous studies that have been taken as proving that exercise is helpful for depression . In these studies, people who are made to exercise improve to a greater extent than those who are not interfered with. However, this finding does not prove that exercise per se aids depression. It might be, for example, that simply being enrolled in a study and motivated to do anything at all might aid depression. (This suspicion is given further weight by findings that improvement in depression is not at all related to the intensity of the exercise done—if it were the exercise itself, one would think that more intense exercise would provide greater benefits.)

Double-blind, placebo-controlled studies eliminate all of these potential confounding factors, as well as many others. However, as noted above, it is not feasible to design a double-blind study in which people are unaware (“blind” to the fact ) that they are exercising. Therefore, all results regarding the potential benefits of exercise must be taken with a grain of salt.

What Is the Scientific Evidence for Exercise?

Keeping the above discussion in mind, the benefits of exercise with the most solid scientific foundation include: 1-4

Regarding blood pressure, aerobic exercise has the best supporting evidence, but resistance exercise (weight training) has also shown promise. 5-9 One interesting study found that four 10-minute "snacks" of aerobic exercise per day were as effective at lowering blood pressure as 40 minutes of continuous exercise. 9

Aerobic exercise can also raise levels of HDL (“good”) cholesterol , as well as reduce levels of triglycerides . 10,11

Other conditions for which exercise has some meaningful supporting evidence of benefit include:

Regarding osteoporosis , the general scientific consensus is that exercise does help, but the supporting evidence is surprisingly weak. 24-27

Inconsistent or otherwise weak evidence suggests potential benefit for:

It is widely believed that exercise improves immune function. However, there is no meaningful supporting evidence for this belief. Very high intensity exercise (such as marathon running) is known to temporarily weaken the immune system, increasing likelihood of respiratory infection. This is discussed in the article Sports and Fitness Support: Enhancing Recovery .

Evidence conflicts on whether exercise is helpful for reducing menopausal symptoms32,33 However, it is known that heavy exercise causes increased calcium loss through sweat, and the the body does not compensate for this by reducing calcium loss in the urine. 35 The result can be a net calcium loss great enough so that it presents health concerns for menopausal women. One study found that use of an inexpensive calcium supplement (calcium carbonate), taken at a dose of 400 mg twice daily, is sufficient to offset this loss. 35

Aerobic exercise however, may be beneficial for sedentary women. In a randomized trial of 176 women who had their last menstrual period within 3-36 months, aerobic exercise was associated with a decrease in menopausal symptoms including night sweats, irritability, depression, mood swings, headache, and urinary problems. The trial compared unsupervised aerobic exercise for 50 minutes, 4 times per week to twice monthly health lectures. 37

References

1.   Karmisholt K, Gyntelberg F, Gotzche PC, et al. Physical activity for primary prevention of disease. Systematic reviews of randomised clinical trials. Dan Med Bull. 2005;52:86-89.

2.   Karmisholt K, Gotzsche PC. Physical activity for secondary prevention of disease. Systematic reviews of randomised clinical trials. Dan Med Bull. 2005;52:90-94.

3.   Kujala UM. Evidence for exercise therapy in the treatment of chronic disease based on at least three randomized controlled trials--summary of published systematic reviews. Scand J Med Sci Sports. 2004;14:339-45.

4.   Hauer K, Becker C, Lindemann U, Beyer N. Effectiveness of physical training on motor performance and fall prevention in cognitively impaired older persons: A systematic review. Am J Phys Med Rehabil. 2006;85:847-857.

5.   Kelley GA, Kelley KS, Tran ZV. Walking and resting blood pressure in adults: a meta-analysis. Prev Med. 2001;33:120-127.

6.   Cornelissen VA, Fagard RH. Effect of resistance training on resting blood pressure: a meta-analysis of randomized controlled trials. J Hypertens. 2005;23:251-259.

7.   Fagard RH. Exercise is good for your blood pressure: effects of endurance training and resistance training. Clin Exp Pharmacol Physiol. 2006;33:853-856.

8.   Kelley GA, Kelley KS. Progressive resistance exercise and resting blood pressure : A meta-analysis of randomized controlled trials. Hypertension. 2000;35:838-843.

9.   Elley R, Bagrie E, Arroll B, et al. Do snacks of exercise lower blood pressure? A randomised crossover trial. N Z Med J. 2006;119:U1996.

10.   Kelley GA, Kelley KS, Tran ZV. Aerobic exercise and lipids and lipoproteins in women: a meta-analysis of randomized controlled trials. J Womens Health (Larchmt). 2005;13:1148-1164.

11.   Kelley GA, Kelley KS, Franklin B. Aerobic exercise and lipids and lipoproteins in patients with cardiovascular disease: a meta-analysis of randomized controlled trials. J Cardiopulm Rehabil. 2006;26:131-139.

12.   Ram FS, Robinson SM, Black PN. Effects of physical training in asthma: a systematic review. Br J Sports Med. 2000;34:162-167.

13.   Larun L, Nordheim LV, Ekeland E, et al. Exercise in prevention and treatment of anxiety and depression among children and young people. Cochrane Database Syst Rev. 2006;3:CD004691.

14.   Lawlor DA, Hopker SW. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ. 2001;322:763-767.

15.   Thomas DE, Elliott EJ, Naughton GA. Exercise for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2006;3:CD002968.

16.   Jones KD, Adams D, Winters-Stone K, et al. A comprehensive review of 46 exercise treatment studies in fibromyalgia (1988-2005). Health Qual Life Outcomes. 2006;4:67. Health and Quality of Life Outcomes website. Available at: http://www.hqlo.com/content/pdf/1477-7525-4-67.pdf . Accessed October 2, 2006.

17.   Devos-Comby L, Cronan T, Roesch SC. Do exercise and self-management interventions benefit patients with osteoarthritis of the knee? A meta-analytic review. J Rheumatol. 2006;33:744-756.

18.   Fransen M, McConnell S, Bell M. Exercise for osteoarthritis of the hip or knee. Cochrane Database Syst Rev. 2003;CD004286.

19.   Bennell K, Hinman R. Exercise as a treatment for osteoarthritis. Curr Opin Rheumatol. 2005;17:634-640.

20.   Hayden JA, van Tulder MW, Malmivaara A, et al. Exercise therapy for treatment of non-specific low back pain. Cochrane Database Syst Rev. 2005;CD000335.

21.   Edmonds M, McGuire H, Price J. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2004;CD003200.

22.   Samad AK, Taylor RS, Marshall T, et al. A meta-analysis of the association of physical activity with reduced risk of colorectal cancer. Colorectal Dis. 2005;7:204-213.

23.   Montgomery P, Dennis J. Physical exercise for sleep problems in adults aged 60+. Cochrane Database Syst Rev. 2002;CD003404.

24.   Kelley GA, Kelley KS. Exercise and bone mineral density at the femoral neck in postmenopausal women: a meta-analysis of controlled clinical trials with individual patient data. Am J Obstet Gynecol. 2006;194:760-767.

25.   Martyn-St James M, Carroll S. High-intensity resistance training and postmenopausal bone loss: a meta-analysis. Osteoporos Int. 2006;17:1225-1240.

26.   Kelley GA, Kelley KS, Tran ZV. Exercise and bone mineral density in men: a meta-analysis. J Appl Physiol. 2000;88:1730-1736.

27.   Bonaiuti D, Shea B, Iovine R, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev. 2002;CD000333.

28.   Oczkowski W. Complexity of the relation between physical activity and stroke: a meta-analysis. Clin J Sport Med. 2005;15:399.

29.   Avenell A, Brown TJ, McGee MA, et al. What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions. J Hum Nutr Diet. 2004;17:293-316.

30.   Toth MJ, Beckett T, Poehlman ET. Physical activity and the progressive change in body composition with aging: current evidence and research issues. Med Sci Sports Exerc. 1999;31:S590-S596.

31.   Blundell JE, King NA. Physical activity and regulation of food intake: current evidence. Med Sci Sports Exerc. 1999;31:S573-S583.

32.   Wilbur J, Miller AM, McDevitt J, et al. Menopausal status, moderate-intensity walking, and symptoms in midlife women. Res Theory Nurs Pract. 2005;19:163-180.

33.   Elavsky S, McAuley E. Physical activity and mental health outcomes during menopause: a randomized controlled trial. Ann Behav Med. 2007;33:132-142.

34.   van Uffelen JG, Chin A Paw MJ, Hopman-Rock M, et al. The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial. Qual Life Res. 2007 July 7. [Epub ahead of print]

35.   Martin BR, Davis S, Campbell WW, et al. Exercise and calcium supplementation: effects on calcium homeostasis in sportswomen. Med Sci Sports Exerc. 2007;39:1481-1486.

36.   Busch AJ, Schachter CL, Overend TJ, et al. Exercise for fibromyalgia: a systematic review. J Rheumatol. 2008 May 1.

37.   Moilanen JM, Mikkola TS, et al. Effect of aerobic training on menopausal symptoms--a randomized controlled trial. Menopause. 2012;19(6):691-696.



Last reviewed September 2014 by EBSCO CAM Review Board

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

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