A risk factor is something that increases your likelihood of getting a disease or condition. It is possible to develop osteoporosis with or without the risk factors listed below. However, the more risk factors you have, the greater your likelihood of developing osteoporosis. If you have a number of risk factors, ask your doctor what you can do to reduce your risk.
Women are at greater risk of developing osteoporosis than men. This is because they have less bone tissue than men and have a sudden drop in hormones—especially estrogen—at menopause.
Estrogen deficiencies occur as a result of:
Men have a higher bone density and lose calcium at a slower rate than women. However, after age 50, bone loss gradually increases. Risk factors for bone loss in men include:
In men, deficiencies of testosterone and, to a much minor extent, estrogen play a role in the development of osteoporosis. This may be related to:
The risk of osteoporosis increases with age. Bone loss increases, while bone building decreases.
Having a family history of osteoporosis, especially hip fracture, puts you at a higher risk. Genetic diseases, such as cystic fibrosis, glycogen storage diseases, or homocystinuria also play a role in higher osteoporosis risk.
Your risk of developing osteoporosis increases if you have a restrictive diet, such as not getting enough calories, calcium or vitamin D. An excess of phosphorous in your diet, usually from colas, may increase your risk if your calcium and/or vitamin D intakes are low. Excessive alcohol use, coffee, or tea may also increase your risk of osteoporosis.
Regular exercise, especially weight-bearing and resistance exercise, helps strengthen bones. Therefore, if you do not exercise on a regular basis, you may increase your risk of developing osteoporosis. Individuals who do not exercise regularly also tend to have weaker muscles and poorer balance, which can lead to falls and fractures.
Smoking impairs bone, muscle, and joint health. If you smoke, you have a higher risk of developing osteoporosis.
Small-boned women and underweight people of both sexes have an increased risk of osteoporosis.
The effect of sun on the skin is a primary source of vitamin D, which aids bone formation. If you get very little sun exposure and have a low dietary intake of vitamin D, you may be at increased risk of osteoporosis.
Caucasian, Asian, and Hispanic women are more likely to develop osteoporosis than those of other ethnic groups. Though most ethnic studies have focused on women, it is believed that men in these ethnic groups carry a parallel but lower risk.
The long-term use of certain medications increases your risk of osteoporosis. Examples include:
Talk to your doctor before stopping or reducing your medications.
Certain chronic conditions may increase your risk for developing osteoporosis.
Gastrointestinal conditions include:
Endocrine or hormonal conditions include:
Other disorders include:
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Medicines and conditions that can cause falls. National Osteoporosis Foundation website. Available at https://www.nof.org/conditions-and-medicines-that-can-cause-falls. Accessed May 19, 2016.
Osteoporosis. NIH Osteoporosis and Related Bone Diseases National Resource Center website. Available at: http://www.niams.nih.gov/Health_Info/Bone/Osteoporosis/default.asp. Updated June 2015. Accessed May 19, 2016.
Osteoporosis causes and risk factors. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated April 29, 2016. Accessed May 19, 2016.
What women need to know. National Osteoporosis Foundation website. Available at: https://www.nof.org/prevention/general-facts/what-women-need-to-know. Accessed May 19, 2016.
1/30/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180(1):32-39.
1/30/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Carbone LD, Johnson KC, Bush AJ, et al. Loop diuretic use and fracture in postmenopausal women: findings from the Women's Health Initiative. Arch Intern Med. 2009;169(2):132-140.
12/29/2009 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed: Hippisley-Cox J, Coupland C. Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores. BMJ. 2009;339:b4229.
Last reviewed May 2016 by Michael Woods, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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