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Cancer is a disease in which cells grow in an abnormal way. Normally, the cells divide in a controlled manner. If cells keep dividing when new cells are not needed, a mass of tissue called a tumor forms.

A tumor can be benign or malignant. A benign tumor is not cancer and will not spread to other parts of the body. A malignant tumor is cancer. Cancer cells invade and damage tissue around them. They can also enter the lymph and blood streams, spreading to other parts of the body. Esophageal cancer is the development of malignant cells in the esophagus.

Cancer Cell Growth

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Normal Anatomy and the Development of Esophageal Cancer

The esophagus is a muscular tube about 12 inches long that connects the throat to the stomach. It plays an important role in moving food downward into the stomach. Chewed food is formed into a small mass called a bolus. Once the bolus is swallowed, it is propelled down the esophagus and into the stomach by a series of coordinated and rhythmic muscular contractions.

The esophagus has 2 muscular rings called the upper and lower esophageal sphincters. The upper esophageal sphincter is controlled by swallowing, which allows food into the tube. The lower esophageal sphincter (LES) opens to allow food into the stomach. Once it passes through, the LES closes to help keep food and stomach acids inside the stomach during digestion.

Cell death and cell growth are a normal process in the body to replace old or damaged cells. The inside lining of the esophagus is an active area of the body that may have a high rate of cell turnover. Irritants introduced to the esophagus can increase inflammation and the rate of cell turnover. This turnover increases the risk of cellular mutations that can lead to uncontrolled growth. Irritants include stomach acid, alcohol, tobacco, and certain foods. Chronic digestive conditions, such as gastroesophageal reflux disease (GERD), also contribute to irritation.

Esophageal cancer tumors can cause blockages in the esophagus, which makes it difficult to swallow food. If the tumor grows beyond the esophageal layers, the cancer can penetrate nearby structures, such as the spine, trachea (the tube that carries air from the throat to the lungs), or the aorta (the body's largest artery). The cancer can cause damage to these structures and interfere with their function. It can also spread to lymph nodes or blood vessels, which can carry cancer cells to other areas of the body. The most common sites for metastatic esophageal cancer are the lungs, liver, kidney, and bones.

Esophageal Cancer

Esophageal cancer

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Types of Esophageal Cancer

There are 2 main types of esophageal cancer that make up nearly all esophageal cancers found:

  • Squamous cell carcinoma—Arise from the flat cells that make up the innermost lining of the esophagus.
  • Adenocarcinoma—Arise from cells closest to the stomach and are associated with acid exposure in the esophagus from GERD. Barrett's esophagus is a change in esophageal cells which has a high risk of progressing into adenocarcinoma.


Esophageal and esophagogastric junction cancer. EBSCO DynaMed Plus website. Available at: Updated January 18, 2016. Accessed January 3, 2017.

Esophageal cancer. Merck Manual Professional Version website. Available at: Updated July 2014. Accessed January 3, 2017.

Esophagus cancer. American Cancer Society website. Available at Accessed January 3, 2017.

General information about esophageal cancer. National Cancer Institute website. Available at: Updated July 19, 2016. Accessed January 3, 2017.

Last reviewed December 2016 by Mohei Abouzied, MD

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

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