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Acute Myeloid Leukemia—Child(AML—Child; Acute Myelogenous Leukemia—Child; Acute Myeloblastic Leukemia—Child; Acute Granulocytic Leukemia—Child; Acute Nonlymphoblastic Leukemia—Child)
Definition

Leukemia is a type of cancer that develops in the bone marrow. With acute myeloid leukemia (AML), the bone marrow makes abnormal myeloid cells that are precursors to blood cells, including:

  • Myeloblasts (a type of white blood cell) that fight infection
  • Red blood cells that carry oxygen
  • Platelets that make blood clots and stop bleeding in cuts and bruises

The leukemia cells do not function normally. They cannot do what normal blood cells do, like fight infections. The abnormal cells also overgrow the bone marrow, forcing normal cells out. Without normal cells, anemia and bleeding problems develop. They also cannot fight infections properly.

White Blood Cells

White Blood Cells

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Causes

Cancer occurs when cells in the body divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue forms, called a growth or tumor. The term cancer refers to malignant growths. These growths can invade nearby tissues. Cancer that has invaded nearby tissues can then spread to other parts of the body.

It is not clear exactly what causes these problems in the cells, but it is probably a combination of genetics and environment.

Risk Factors

AML is more common in those of Hispanic descent. Other factors that may increase your child's risk of AML include:

  • Genetic factors:
    • Having a sibling, especially an identical twin, who develops leukemia
    • Having a genetic condition, such as Down syndrome
  • Exposure to radiation
  • Exposure to certain chemicals, such as benzene, a chemical used in the cleaning and manufacturing industries
  • History of other blood disorders, such as polycythemia vera, essential thrombocytosis, or myelodysplastic syndrome
Symptoms

AML may cause:

  • Fever
  • Frequent infections
  • Shortness of breath
  • Paleness (a sign of anemia)
  • Easy bruising or bleeding
  • Petechiae (flat, pinpoint spots under the skin caused by bleeding)
  • Weakness, fatigue
  • Loss of appetite, weight loss
  • Bone and joint pain
  • Painless lumps in the neck, underarms, stomach, or groin
  • Bleeding gums
Diagnosis

The doctor will ask about your child’s symptoms and medical history. A physical exam will be done. The doctor will check for swelling of the liver, spleen, and lymph nodes.

Test to assess bodily tissues or other structures include:

Imaging tests evaluate bodily structures. These may include:

Once AML is identified, it can be classified. These subtypes are based on the type of cell from which leukemia developed. This is important because it can help the doctor make a prognosis and develop a treatment plan.

Bone Marrow Biopsy

Bone biopsy

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Treatment

Talk with the doctor about the best plan for your child. Treatment of AML usually involves 2 phases:

  • Remission induction therapy—to kill leukemia cells
  • Maintenance therapy—to kill any remaining leukemia cells that could grow and cause a relapse

Treatment options include:

  • Chemotherapy
  • External beam radiation therapy—targets a certain part of the body
  • Stem cell transplant to replaces the affected bone marrow with healthy bone marrow
  • Other drug therapy may be used to kill leukemia cells, stop them from dividing, or help them mature into white blood cells
  • Biological therapy—involves using medicine or substances made by the body to increase or restore the body’s natural defenses against cancer
  • Antibiotics to treat and prevent infections
  • Medications to treat anemia and treatment side effects, such as like nausea and vomiting
Prevention

There are no current guidelines to prevent AML because the cause is unknown.

RESOURCES:

American Cancer Society
http://www.cancer.org

The Leukemia and Lymphoma Society
http://www.lls.org

CANADIAN RESOURCES

BC Cancer Agency
http://www.bccancer.bc.ca

Canadian Cancer Society
http://www.cancer.ca

References:

Acute myeloid leukemia (AML). EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated November 19, 2014. Accessed November 28, 2014.

Childhood leukemia. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003095-pdf.pdf. Accessed November 28, 2014.

Leukemia in children. Boston Children's Hospital website. Available at: hhttp://www.childrenshospital.org/health-topics/conditions/leukemia. Accessed November 28, 2014.



Last reviewed November 2014 by Mohei Abouzied, MD

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

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